The evidence base for multiple micronutrient supplementation (MMS) for pregnant women has been established for over 20 years and demonstrates that MMS significantly reduces the number of babies born with low birth weight, those who are small for their gestational age, or stillborn in low- and middle-income countries.

Replacing iron and folic acid (IFA) supplementation with MMS provides an opportunity to strengthen nutrition-specific interventions provided during antenatal care (ANC) services in combination with other proven nutrition interventions such as dietary counseling for healthy eating and appropriate weight gain during pregnancy.

To provide a robust answer to feasibility and cost-effectiveness questions that policy and decision-makers may have, it is recommended to support the introduction of MMS with implementation research. This aligns with the WHO guidance that MMS implementation needs to be done in the context of rigorous research.

Programmatic Considerations to Integrate MMS into Antenatal Care

The Interim country-level decision-making guidance for introducing MMS for pregnant women, developed by the MMS Technical Advisory Group (TAG) in 2021, identified the following 8 programmatic considerations to integrate MMS into antenatal care: 

  • Counseling about healthy eating and keeping physically active during pregnancy is recommended for pregnant women to stay healthy and prevent excessive weight gain during pregnancy. Specifically, in undernourished populations, nutrition education on increasing daily energy and protein intake is recommended for pregnant women to reduce the risk of low birth-weight newborns. 

    Effective, at-scale social and behavior change communication (SBCC) campaigns – grounded in the local context – can be used at the population, facility, and individual level to strengthen nutrition counseling and improve the uptake of and compliance with all maternal nutrition interventions. 

    The UNICEF technical programme brief on Counselling to improve maternal nutrition aims to improve the coverage and quality of nutrition counseling before and during pregnancy and while breastfeeding. 

  • To ensure the long-term success of efforts to incorporate MMS into healthcare systems, creating an enabling environment is an essential first step during which national stakeholders (e.g., champions, influencers, and decision-makers) are identified and engaged to 

    1. raise awareness about MMS and advocate for its use;
    2. facilitate an understanding of the evidence as it relates to the benefits of MMS over IFA, and a consensus around the evidence and about what issues may need further examination (e.g., issues related to supply and demand) in a national program to ensure sustainability and impact; and
    3. develop a consensus on the need, feasibility, and plan to introduce MMS. 
  • Given the variable etiologies of anemia, countries should analyze data on the magnitude and distribution of anemia and its determinants (e.g., iron and other micronutrient deficiencies, malaria, or soil-transmitted helminthic (STH) infections). Where malaria and STH infections are endemic and anemia is a severe public health problem (≥40% among pregnant women), measures to prevent, diagnose, and treat these infections should be implemented concomitantly with MMS as per the WHO and/or national ANC guidelines. 

  • The updated WHO guideline offers an opportunity for countries to introduce MMS as part of a strategy to improve access to and quality of nutrition services in ANC. The WHO guideline recommends that women have eight ANC contacts, including those through the community, potentially offering additional opportunities to deliver MMS. Countries should undertake an analysis of ANC barriers based on which effective strategies can be identified to improve ANC services and MMS coverage/adherence, thereby forming the basis of implementation research. In some countries, there may be opportunities to test the use of MMS as part of social protection schemes and market-based approaches. 

  • Ensuring an uninterrupted and quality supply of MMS is necessary for women to harness its benefits. Countries should undertake a supply chain analysis to identify and remove impediments to MMS access at health facilities, especially where IFA stockouts are routinely reported. Some countries may be interested in establishing local manufacturing capacities for MMS, for which an analysis of local production capacities and regulatory aspects of MMS is important. Where local production is not feasible, understanding the regulatory landscape can help to identify barriers and solutions to facilitate MMS importation. 

  • Investing in the training of the health workers is essential for a smooth transition from IFA to MMS. Improving the quality of nutrition counseling and communications is also key to ensuring effective distribution and adherence to MMS. This includes training health workers and community workers on the benefits of MMS, managing side effects, and strategies on how to remember to take MMS daily throughout pregnancy, along with counseling on nutritious diets. 

  • Ensuring pregnant women and adolescent girls have an enabling environment that supports MMS use is critical. This requires attention to social behavior change communications, which are tailored to the specific needs of pregnant women and adolescent girls and key influencers (e.g. 6 husbands, mothers-in-law, grandmothers, and community members) on the importance of nutritious diets, including the routine use of MMS. Formative research can be instrumental in identifying social and cultural barriers, social norms, and key influencers to target and overcome issues of MMS and can be used to promote acceptance and adherence that may affect MMS uptake. 

  • A critical component of ANC is routine screening and treatment of anemic women. The WHO guideline recommends routinely testing women for anemia at ANC contacts 1 (12 weeks), 3 (26 weeks), and 6 (36 weeks), and treating women with low hemoglobin as per the WHO and/or national protocols. 

  • Many administrative reporting systems, such as health management information systems (HMIS), collect information on the provision of iron-containing supplements to pregnant women during ANC contacts. Increasingly, this information is integrated into District Health Information Systems. In countries introducing MMS, it is imperative that MMS monitoring is integrated into the HMIS. Furthermore, there may be opportunities to introduce MMS monitoring into health facility assessments and household surveys (e.g., Demographic Health Surveys). 

A Framework for MMS Implementation

  • Phase 1: Exploration to build an enabling environment for MMS introduction

    Landscape analysis to understand the specific context and feasibility of introducing MMS that may include assessment of the following:

    • Nutrition situation
    • Policy and regulatory environment
    • Delivery platforms
    • Supply readiness
    • Procurement
    • Stakeholders
    • Cost-effectiveness
    • Targeting strategies

    Advocacy activities leading to MMS policy recommendations may include:

    • Raising awareness
    • Encouraging the establishment of a national technical working group
    • Consensus-building regarding the need for transition or introduction of MMS
    • Consensus-building regarding next steps
  • Phase 2: Initial implementation supported by implementation research

    Well-designed implementation research supports the development of efficient and effective implementation strategies to optimize coverage, acceptance, and utilization of MMS and may include:

    • Barriers and enablers analysis of uptake and adherence by consumers
    • Current and preferred product attributes assessment
    • Delivery platform strengths and weaknesses analysis
    • Optimal delivery strategies development (e.g. Social and Behavior Change Communication (SBCC))
    • Strengthening existing delivery platforms (capacity building, monitoring, integration)
    • Supply chain assessment
    • Support global procurement or local manufacturing
    • Monitoring of intervention reach and coverage
    • Process and outcome evaluation
    • Documenting lessons learned
  • Phase 3: Scale-up delivery at the national or sub-national level

    Planning and integration of MMS in the existing delivery system includes:

    • Operational planning of scaling
    • Financial planning and budget allocation
    • Capacity building
    • Sustained MMS supply chain & distribution
    • Roll out SBCC strategy
    • Integration of MMS monitoring in Health Information Systems
    • Monitoring, evaluation & capturing lessons learned

Resources

The MMS TAG has developed two key resources on using implementation science to support MMS exploration, introduction, and scale-up.

  • Resource paper for practitioners

    A resource to help national stakeholders, including MMS TAG or Task Force members, government, research and academic, private sector and implementation partners, understand how Implementation Science supports MMS introduction and scale-up. Available in French, Arabic, Spanish, and Portuguese.

    Read now
  • FAQ for national decision-makers:

    An FAQ addressing common questions from country decision-makers on introducing and scaling MMS programming. Available in French, Arabic, Spanish, and Portuguese.

    Read now

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